Assoc. Prof. Dr. Boryana Nikolova-Mladenova
Tel.: (+359-2) 9236-578

Assoc. Prof. Boryana Nikolova-Mladenova graduated from Faculty of Chemistry at Sofia University “St. Kliment Ohridski” in 1995.

Since 1996 she has been an assistant, since 2008 – an assistant professor, and since 2018 – an associate professor at the Department of Chemistry.

She defended her doctoral dissertation “Synthesis and characterization of new aroylhydrazones, derivatives of salicylaldehyde benzoylhydrazone with potential biological activity” in the scientific specialty “Bioorganic chemistry, chemistry of natural and physiologically active substances”.

She currently holds the position of Associate Professor at the Department of Chemistry and is a course leader for first-year students studying in English.

She gives lectures and practical exercises in “General and Inorganic Chemistry”.

The research work and contributions of Assoc. Prof. Boryana Nikolova-Mladenova are in the following areas of pharmaceutical science and practice: Design and synthesis of new organic compounds and metal complexes with potential biological activity; structural characterization of the compounds; in silico and in vitro study of biological activity and establishment of structure-activity dependence.

She is the author of over 30 publications, 5 handbooks, a chapter in a monograph; has over 80 citations in indexed journals in J. Citation Reports by Clarivate, Scopus by Elsevier, Web of science by Clavirate, Google scholar and others.

She is an expert in the field of bioorganic and coordination chemistry.

Participant and/or leader in 9 research projects funded by the Council of Medical Science at MU-Sofia.

She is a member of the Bulgarian Scientific Society of Pharmacy.

Scientific publications:

Nikolova-Mladenova B., Momekov G., Ivanov D., Bakalova A., Design and drug-like properties of new 5-methoxysalicylaldehyde based hydrazones with anti-breast cancer activity, J Appl Biomedicine 2017; 15(3), 233-240.

Nikolova-Mladenova B.I., Momekov G.Ts., Synthesis, characterization and in vitro cytotoxic activity of zinc(II), cobalt(II) and nickel(II) complexes with tridentate ONO Schiff base 3-methoxysalicylaldehyde benzoylhydrazone, Bulg Chem Comm, Special Edition B 2017; 49: 83-88.

Nikolova-Mladenova B.I., Angelova S.E, Synthesis of 5-nitrosalicylaldehyde based hydrazones and DFT-calculations of their structure and reactivity, Bulg Chem Comm 2017; 49 (4): 800-806.

Nikolova-Mladenova B.I., Angelova S.E., Ga(III) complexes of methoxy substituted aroylhydrazones: synthesis, characterization and DFT calculations, Bulgarian Chemical Communications 2017; 49 (Special issue L): 237-242.

Hristova-Avakumova N.G, Valcheva E.P., Anastassova N.O., Nikolova-Mladenova B.I., Atanasova L.A., Angelova S.E., Yancheva D.Y., In vitro and in silico studies of radical scavenging activity of salicylaldehyde benzoylhydrazones, Journal of Molecular Structure 2021.

Research projects:

“Synthesis and characterization of new methoxy derivatives of salicylaldehyde benzoylhydrazone and their Ga (III) complexes with potential biological activity”.

 “Study of the antioxidant properties of newly synthesized derivatives of salicylaldehyde benzoylhydrazone (SBH) and analysis of the structure-action relationship”.

“Incorporation of bromine-derived hydrazones into polymer particles and in vitro evaluation of their antioxidant activity”.

“Design, drug similarity assessment and synthesis of new hydroxy-substituted hydrazones with potential cytotoxic activity”.



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